In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis.
Identifieur interne : 001359 ( Main/Exploration ); précédent : 001358; suivant : 001360In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis.
Auteurs : RBID : pubmed:21810549English descriptors
- KwdEn :
- Adolescent, Adult, Cell Tracking (methods), Female, Humans, Injections, Isotope Labeling, Liver Cirrhosis (diagnosis), Liver Cirrhosis (pathology), Liver Cirrhosis (surgery), Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stromal Cells (cytology), Mesenchymal Stromal Cells (metabolism), Middle Aged, Organometallic Compounds (metabolism), Oxyquinoline (analogs & derivatives), Oxyquinoline (metabolism), Pilot Projects, Time Factors, Whole Body Imaging.
- MESH :
- chemical , analogs & derivatives : Oxyquinoline.
- chemical , metabolism : Organometallic Compounds, Oxyquinoline.
- cytology : Mesenchymal Stromal Cells.
- diagnosis : Liver Cirrhosis.
- metabolism : Mesenchymal Stromal Cells.
- methods : Cell Tracking.
- pathology : Liver Cirrhosis.
- surgery : Liver Cirrhosis.
- Adolescent, Adult, Female, Humans, Injections, Isotope Labeling, Male, Mesenchymal Stem Cell Transplantation, Middle Aged, Pilot Projects, Time Factors, Whole Body Imaging.
Abstract
Several animal and few human studies suggest the beneficial role of bone marrow mesenchymal stem cells (MSCs) in liver cirrhosis. However, little is known about the fate of MSCs after infusion in cirrhotic patients. We evaluated stem cell biodistribution after peripheral infusion of MSCs in four cirrhotic patients.
DOI: 10.1016/j.nucmedbio.2011.03.008
PubMed: 21810549
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis.</title><author><name sortKey="Gholamrezanezhad, Ali" uniqKey="Gholamrezanezhad A">Ali Gholamrezanezhad</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute for Nuclear Medicine. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114, Iran. agholam1@jhmi.edu</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Research Institute for Nuclear Medicine. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114</wicri:regionArea></affiliation></author><author><name sortKey="Mirpour, Sahar" uniqKey="Mirpour S">Sahar Mirpour</name></author><author><name sortKey="Bagheri, Mohammad" uniqKey="Bagheri M">Mohammad Bagheri</name></author><author><name sortKey="Mohamadnejad, Mehdi" uniqKey="Mohamadnejad M">Mehdi Mohamadnejad</name></author><author><name sortKey="Alimoghaddam, Kamran" uniqKey="Alimoghaddam K">Kamran Alimoghaddam</name></author><author><name sortKey="Abdolahzadeh, Leila" uniqKey="Abdolahzadeh L">Leila Abdolahzadeh</name></author><author><name sortKey="Saghari, Mohsen" uniqKey="Saghari M">Mohsen Saghari</name></author><author><name sortKey="Malekzadeh, Reza" uniqKey="Malekzadeh R">Reza Malekzadeh</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1016/j.nucmedbio.2011.03.008</idno><idno type="RBID">pubmed:21810549</idno><idno type="pmid">21810549</idno><idno type="wicri:Area/Main/Corpus">001234</idno><idno type="wicri:Area/Main/Curation">001234</idno><idno type="wicri:Area/Main/Exploration">001359</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cell Tracking (methods)</term><term>Female</term><term>Humans</term><term>Injections</term><term>Isotope Labeling</term><term>Liver Cirrhosis (diagnosis)</term><term>Liver Cirrhosis (pathology)</term><term>Liver Cirrhosis (surgery)</term><term>Male</term><term>Mesenchymal Stem Cell Transplantation</term><term>Mesenchymal Stromal Cells (cytology)</term><term>Mesenchymal Stromal Cells (metabolism)</term><term>Middle Aged</term><term>Organometallic Compounds (metabolism)</term><term>Oxyquinoline (analogs & derivatives)</term><term>Oxyquinoline (metabolism)</term><term>Pilot Projects</term><term>Time Factors</term><term>Whole Body Imaging</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Oxyquinoline</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Organometallic Compounds</term><term>Oxyquinoline</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesenchymal Stromal Cells</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mesenchymal Stromal Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cell Tracking</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Humans</term><term>Injections</term><term>Isotope Labeling</term><term>Male</term><term>Mesenchymal Stem Cell Transplantation</term><term>Middle Aged</term><term>Pilot Projects</term><term>Time Factors</term><term>Whole Body Imaging</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several animal and few human studies suggest the beneficial role of bone marrow mesenchymal stem cells (MSCs) in liver cirrhosis. However, little is known about the fate of MSCs after infusion in cirrhotic patients. We evaluated stem cell biodistribution after peripheral infusion of MSCs in four cirrhotic patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21810549</PMID><DateCreated><Year>2011</Year><Month>10</Month><Day>10</Day></DateCreated><DateCompleted><Year>2012</Year><Month>02</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9614</ISSN><JournalIssue CitedMedium="Internet"><Volume>38</Volume><Issue>7</Issue><PubDate><Year>2011</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Nuclear medicine and biology</Title><ISOAbbreviation>Nucl. Med. Biol.</ISOAbbreviation></Journal><ArticleTitle>In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis.</ArticleTitle><Pagination><MedlinePgn>961-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nucmedbio.2011.03.008</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several animal and few human studies suggest the beneficial role of bone marrow mesenchymal stem cells (MSCs) in liver cirrhosis. However, little is known about the fate of MSCs after infusion in cirrhotic patients. We evaluated stem cell biodistribution after peripheral infusion of MSCs in four cirrhotic patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">After three passages of MSCs, the patients received a total of 250-400×10(6) cells, of which only 50% of the cells were labeled. Specific activities of 0.21-0.67 MBq/10(6) cells were maintained for the injected labeled MSCs. Planar whole-body acquisitions (anterior/posterior projections) were acquired immediately following infusion as well as at 2 h, 4 h, 6 h, 24 h, 48 h, 7th and 10th days after cell infusion.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">After intravenous infusion, the radioactivity was first observed to accumulate in the lungs. During the following hours to days, the radioactivity gradually increased in the liver and spleen, with spleen uptake exceeding that in the liver in all patients. Region-of-interest analysis showed that the percentage of cells homing to the liver (following decay and background corrections and geometric mean calculation) increased from 0.0%-2.8% at immediately post-infusion images to 13.0-17.4% in 10th-day post-infusion. Similarly, the residual activities in the spleen increased from 2.0%-10.2% at immediately post-infusion images to 30.1%-42.2% in 10th-day post-infusion. During the same period, the residual activities in the lungs decreased from 27.0-33.5% to 2.0-5.4%.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The infusion of MSCs labeled with (111)In-oxine through a peripheral vein is safe in cirrhosis. Cell labeling with (111)In-oxine is a suitable method for tracking MSC distribution after infusion.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gholamrezanezhad</LastName><ForeName>Ali</ForeName><Initials>A</Initials><Affiliation>Research Institute for Nuclear Medicine. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114, Iran. agholam1@jhmi.edu</Affiliation></Author><Author ValidYN="Y"><LastName>Mirpour</LastName><ForeName>Sahar</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Bagheri</LastName><ForeName>Mohammad</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mohamadnejad</LastName><ForeName>Mehdi</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Alimoghaddam</LastName><ForeName>Kamran</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Abdolahzadeh</LastName><ForeName>Leila</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Saghari</LastName><ForeName>Mohsen</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Malekzadeh</LastName><ForeName>Reza</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>06</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nucl Med Biol</MedlineTA><NlmUniqueID>9304420</NlmUniqueID><ISSNLinking>0969-8051</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>14514-42-2</RegistryNumber><NameOfSubstance>indium oxine</NameOfSubstance></Chemical><Chemical><RegistryNumber>5UTX5635HP</RegistryNumber><NameOfSubstance>Oxyquinoline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Tracking</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Injections</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Isotope Labeling</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Liver Cirrhosis</DescriptorName><QualifierName MajorTopicYN="N">diagnosis</QualifierName><QualifierName MajorTopicYN="Y">pathology</QualifierName><QualifierName MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Mesenchymal Stem Cell Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mesenchymal Stromal Cells</DescriptorName><QualifierName MajorTopicYN="Y">cytology</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Organometallic Compounds</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Oxyquinoline</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Whole Body Imaging</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>1</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>3</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>3</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>6</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>2</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0969-8051(11)00110-7</ArticleId><ArticleId IdType="doi">10.1016/j.nucmedbio.2011.03.008</ArticleId><ArticleId IdType="pubmed">21810549</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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